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KMID : 0613820090190070934
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Journal of Life Science
2009 Volume.19 No. 7 p.934 ~ p.942
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Effect of Garlic and Medicinal Plants Composites on the Liver Function and Lipid Metabolism of Rats Administered with Ethanol During the Short-term
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Kang Min-Jung
Shin Jung-Hye
Lee Soo-Jung
Chung Mi-Ja
Sung Nak-Ju
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Abstract
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This study was performed to observe the effect of hot-water extracts from garlic and 13 kinds of medicinal plants composites (GMP) on hyperlipidemia and hepatoprotective activity in rats administered with alcohol. Male Sprague-Dawly rats were fed an AIN-93 diet (Normal), a normal diet plus ethanol (control, 10 ml of 40% ethanol/㎏/day), a control diet plus 0.5% garlic and 1.0% medicinal plants composites extracts (GMP-I), and a control diet plus 1.0% garlic and medicinal plants composites extracts (GMP-Ⅱ) for 7 days. Blood glucose was higher than the control, but it was markedly decreased in the GMP-Ⅱ group. Elevation total lipids, cholesterol, triglyceride and phospholipids in serum were markedly decreased in rats fed with GMP-Ⅰ. GMP-Ⅱ also inhibited the increase of lipid content in serum. Activities of GOT, GPT, r-GTP and ALP in serum elevated by alcohol were significantly inhibited in the GMP group. TBARS content of serum was significantly decreased in GMP groups administered with garlic and medicinal plant extracts. Extracts of garlic and medicinal plants play an important role in recovering liver function in rats from alcohol induced damage.
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KEYWORD
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Garlic, medicinal plants, alcohol, liver damage
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